What is warfarin?
Warfarin is a common anticoagulant prescribed to prevent the formation of blood clots (thrombosis) and their migration elsewhere in the body (thromboembolism). Warfarin is useful for long-term anticoagulant treatment. It is often used to treat people at a high risk of thrombosis, due to genetics, artificial heart valves, an abnormal heart rhythm, surgery or have previously suffered from a blood clot.
Determining the correct warfarin dose
Every individual requires slightly differing warfarin doses to establish an effective and safe anticoagulant effect, and sometimes it can take months to determine the correct dose. Warfarin activity is influenced by:
- Genetic variation
- Height & weight
- Other medications
This genetic analysis detects variations across four genes (VKORC1, CYP2C9, GGCX and CYP4F2), which explain a large proportion of warfarin dose variation. The results of this analysis can be used in the warfarin dosing algorithm at WarfarinDosing.org to significantly reduce the “trial and error” approach typically taken to achieve an optimum warfarin dose.