Syphilis Test


Syphilis is an STD that can result in serious health complications if left untreated. It is a multistage disease with different symptoms associated with each stage. Take this at-home STD test to find out if you may need treatment for syphilis.

STD tested:


Collection method:  Finger Prick


Why consider this test?

The CDC recommends syphilis testing for:

  • Anyone showing symptoms that are suggestive of syphilis
  • All individuals with an oral, anal, or vaginal sexual partner with a recent syphilis diagnosis
  • All pregnant women
  • Sexually active HIV-positive individuals (routine testing)
  • Sexually active men who have sex with men (routine testing)

Syphilis may be detected as early as 1-2 weeks post-exposure. However, it may not be detected for up to 3 months in some individuals.

Prevent the complications of syphilis. Get tested today.

Syphilis can affect both men and women, with the most at-risk populations being men who have sex with men, and HIV-positive people. Transmission occurs when direct contact is made with a syphilitic sore through kissing, vaginal, anal, or oral sex.

Pregnant women with syphilis can transmit the disease to their infant during pregnancy. Syphilis increases the risk of miscarriage, stillbirth, and infant death shortly after delivery. Infected infants must be treated immediately to prevent developmental delays, seizures, and other fatal complications.

Treatment is effective for curing a current infection, but does not prevent a reinfection. There are no effective vaccines available for syphilis.

Symptoms of syphilis

Syphilis has been dubbed “The Great Pretender” as symptoms can resemble other diseases. Syphilis infections have four distinct stages – primary, secondary, latent, and tertiary.

Primary stage
The primary stage is marked by the appearance of one or more skin lesions (chancres) where the bacteria entered the body (genitals, rectum, or mouth). Chancres are generally painless and last 3 to 6 weeks. If untreated, the infection progresses to the secondary stage.

Secondary stage
Skin rashes of varying appearance are common in the secondary stage. Other symptoms may include swollen lymph nodes, weight loss, headaches, and fever. If untreated, the infection progresses to the latent stage.

Latent (hidden) stage
There are no symptoms associated with the latent stage. However, the infection still persists in the body, and individuals are still infectious particularly in the early latent stage (within 2 years of original infection). The latent stage can last for many years.

Tertiary stage
Tertiary syphilis develops in 15-40% of untreated individuals. Multiple different organ systems can be affected including the brain, nerves, eyes, heart, liver, bones, and joints. The associated symptoms vary depending on the affected body parts.

What’s included in the Syphilis Test?

• Syphilis

Syphilis is caused by the bacterium Treponema pallidum subspecies pallidum. Syphilitic sores, called chancres, are usually the first sign of a syphilis infection.

Syphilis diagnosis is by two types of laboratory analyses of a blood sample – nontreponemal and treponemal assays. This Syphilis Test is a treponemal assay, which detects antibodies to recombinant antigens representing TpN15, TpN17, and TpN47 of the T. pallidum genome. This test will identify both current and past, resolved infections. Additional testing with a nontreponemal assay should be conducted on all samples that are reactive in this treponemal Syphilis Test.

How It Works

Order your test

Choose the test that matches your need from our large array of tests. The kit will be delivered to your doorstep. There is no need to leave the comfort of your home.

Collect your sample

Register and activate your test. Collect your sample. Return your sample to our lab as soon as possible, using the prepaid envelope included in the kit.

Quality guarantee

Your sample will be tested as soon as it arrives in our lab. Your results will be available through our secure online platform.


Here are the answers to the most frequently asked questions about this test. Please feel free to contact us if you have any other questions.

How does the syphilis test work?
To take a blood sample, use the supplies provided in the kit. Place your sample in the specimen bag provided and mail it back to the lab using the prepaid envelop inside the kit.

Screening and diagnosis of syphilis involves two types of tests: a treponemal test or a non-treponemal test. Both tests are necessary to confirm a diagnosis.

The treponemal test looks for antibodies that react with molecules (antigens) specific to the Treponema bacterium. Antibodies are made by the immune system in response to an infection. Our lab test uses an antigen specific to the bacteria to look for antibodies specific to syphilis. Treponemal tests are used for screening as it gives you a “positive” or “negative” result.

When a treponemal test gives a positive result, it is followed up with a non-treponemal test. These tests are quantitative, or measures how much antibody is in your blood, and are useful for identifying the stage of infection. Some of the most commonly used non-treponemal tests include the Rapid Plasma Reagin (RPR) test and the Venereal Disease Research Laboratory (VDRL) test. Results from the non-treponemal tests are used for selecting correct treatment options.

How are syphilis treated?
Syphilis is effectively treated with antibiotics (penicillin). Refrain from sexual activity until treatment course is completed. It is important to have all sexual partners treated at the same time to avoid reinfection. While syphilis can be cured, any organ damage is not repaired by the antibiotic treatment and may be permanent.

How can syphilis be prevented?
Avoiding vaginal, rectal or oral sex is the only sure-fire way to prevent STDs.

In sexually active people:

  • Male condoms help reduce the risk of transmission, but uncovered chancres can still result in disease transmission
  • A long-term monogamous relationship with a tested partner reduces the risk.

Who should get tested for syphilis?
The CDC recommends syphilis testing for:

  • Anyone showing symptoms that are suggestive of a syphilis infection
  • All individuals with an oral, anal, or vaginal sexual partner with a recent syphilis diagnosis
  • Women during each pregnancy
  • Sexually active HIV-positive individuals (routine testing)
  • Sexually active men who have sex with men (routine testing)

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